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Chemical Biology and Biosynthesis Research Team

Main Research Fields :
Complex systems
Related Research Fields :
Chemistry / Biology / Agricultural sciences / Medicine, dentistry, and pharmacy / Chemical Biology / Biomolecular Chemistry / Natural product chemistry
Keywords :
Chemical biology / Bioactive compounds / Synthetic biology / Biosynthetic redesign
Project :
Metabolic Genome Engineering / Advanced Research and Technology Platforms
M
TP

Production of novel bioactive compounds with biosynthetic ways

Team Leader

Takayoshi Awakawa Ph.D. Agriculture

Takayoshi Awakawa

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2011
Ph.D in Agriculture, The University of Tokyo
2011
Assistant Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
2014
University of California at San Diego, Scripps Institute of Oceanography Prof. Bradley Moore
2016
Assistant Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
2018
Lecturer, Graduate School of Pharmaceutical Sciences, The University of Tokyo
2019
Associate Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
2022
Team Leader, Chemical Biology and Biosynthesis Research Team, RIKEN Center for Sustainable Resource Science (-current)

CONTACT

RIKEN Center for Sustainable Resource Science
Chemical Biology and Biosynthesis Research Team

takayoshi.awakawa

WakoAccess
2-1 Hirosawa, Wako, Saitama 351-0198 Japan
#302 Chemical Biology Building

Related Links

Laboratory on RIKEN Website
Chemical Biology and Biosynthesis Research Team | RIKEN

Outline

Chemical Biology and Biosynthesis Research Team
Our laboratory aims to contribute to solving social issues such as the decrease and depletion of natural resources and to advance environmental resource science research through research on chemical biology and biosynthesis, including research on new useful natural products using biosynthetic methods. We analyze the biosynthesis pathway of bioactive substances and construct substance production systems in microbial hosts. We create non-natural compounds by modifying biosynthetic pathways and enzyme functions in the production system. We also analyze the mechanism of action of the bioactive compounds and obtain new knowledge in chemical biology.

Subjects

  1. Redesign of biosynthetic machinery
  2. Alteration of enzyme function
  3. Functional elucidation of bioactive compounds