Chemical Genomics Research Group
- Main Research Fields :
- Biology
- Related Research Fields :
- Chemistry
- Keywords :
- Chemical Biology / Epigenetics / Mode of Action / Transcriptional Regulation / Chemical Screening for Drug Discovery
- Project :
- Advanced Research and Technology Platforms
TP
Exploiting methodologies to resolve environmental and resource-related problems using chemical biology
Group Director
Minoru Yoshida D.Agr.

- 1986
- Ph.D., University of Tokyo
- 1986
- Assistant Professor, University of Tokyo
- 1995
- Associate Professor, University of Tokyo
- 2002
- Chief Scientist, Chemical Genetics Laboratory, RIKEN
- 2002
- Visiting Professor, University of Tokyo (-current)
- 2003
- Visiting Professor, Saitama University (-current)
- 2008
- Group Director, Chemical Genomics Research Group, RIKEN
- 2011
- Visiting Professor, Kyoto University (-current)
- 2013
- Group Director, Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science (-current)
- 2013
- Division Director, Drug Discovery Platforms Cooperation Division, RIKEN Center for Sustainable Resource Science (-current)
- 2013
- Unit Leader, Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science
- 2018
- Unit Leader, Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science (-current)
- 2020
- Deputy Director, RIKEN Center for Sustainable Resource Science
CONTACT
RIKEN Center for Sustainable Resource Science
Chemical Genomics Research Group
yoshidam
Related Links
Laboratory on RIKEN Website
Chemical Genomics Research Group | RIKEN
Outline

Subjects
- Development of screening systems for bioactive compounds that target protein-protein interactions
- Development of comprehensive methodologies for target identification of bioactive compounds
- Chemical regulation of epigenetics by controlling protein methylation, acetylation, and acylation
- Chemical regulation of metabolism for effective bioenergy production

- Live imaging of histone acetylation using Histac-K12, a fluorescent probe for visualizing histone H4K12 acetylation in living cells
- Dynamic change in the histone acetylation level in response to a histone deacetylase inhibitor was visualized by using Histac-K12 in living cells and displayed as pseudocolored images. Histac-K12 enables researchers to not only analyze spatial and temporal dynamics of the histone H4K12 acetylation in living cells, but also to evaluate and screen for small molecules that modulate histone acetylation.